In short, we use Diffusion Tensor MRI (DTI) to estimate the electrical conductivity of brain tissue, apply Finite Element Method (FEM) computational modeling to predict the electric impedance measured by an electrode at any location in the brain, and compare the predicted impedances with impedances measured during Deep Brain Stimulation (DBS) surgery to precisely determine the location of electrodes within the brain, enabling increased accuracy and therapeutic efficacy of DBS.
This work has been accepted for publication at the Journal of Neural Engineering.